Catalog# ：AC67563

Clone：TGN1412

Isotype：Humanized IgG4

Endotoxin：Less than 0.001 EU per μg determined by LAL gel clotting assay.

Purity：>99% as determined by SDS-PAGE

          >99% as determined by SEC-HPLC

Antibody Type：Monoclonal

Expressed Host：Stable CHO cell line

Application：T-cell activation

Reactivity：Human

Concentration：1.0 mg/mL

Form：Liquid

Antibody Type：Monoclonal

Formulation：Supplied as 0.2 μm filtered solution in PBS, pH7.4.

Storage instructions：Shipped at 4°C. Stored at 4°C for 12 months.

Other Names：TP44,Tp44

T-cell-specific surface glycoprotein CD28 is a 44kD disulfide-linked homodimeric type I glycoprotein.It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44.CD28 is expressed on most T lineage cells,NK cell subsets,and plasma cells.The binding of CD28 to its ligands CD80 and CD86 transfers a costimulatory signal to the T cell.Activation and proliferation of T cells can be induced by interaction of the T cell receptor(TCR) with peptide-MHC complexes expressed on the surface of antigen presenting cells(APC).T cell activation can also be achieved by agonistic stimulation with the CD3 antibody binding to the TCR complex and can be enhanced by costimulation with CD28 antibody.

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